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Ireneusz Domański-Giec, Beata Wożakowska-Kapłon
Dabigatran jest popularnym antykoagulantem niebędącym antagonistą witaminy K, którego mechanizm działania opiera się na hamowaniu trombiny. Stosowany jest m.in. w profilaktyce powikłań o charakterze zakrzepowo-zatorowym u chorych z migotaniem przedsionków. Pomimo długiej obecności na rynku, niezmiennie pozostaje lekiem aktualnym, wysoce skutecznym i bezpiecznym.
Telmisartan z hydrochlorotiazydem w terapii nadciśnienia tętniczego
Ireneusz Domański-Giec, Beata Wożakowska-Kapłon
Równoczesne zastosowanie leków hipotensyjnych z różnych grup jest obecnie postępowaniem zalecanym przez towarzystwa medyczne. Korzystnymi aspektami takiego postępowania są mniejsze dawki poszczególnych substancji, oddziaływanie na różne drogi rozwoju nadciśnienia oraz lepsze przestrzeganie przez pacjentów zaleceń. Preparat złożony telmisartanu z hydro chlorotiazydem zapewnia oddziaływanie hipotensyjne przez hamowanie układu renina-angiotensyna-aldosteron oraz działa nie moczopędne. Dzięki temu ogranicza ryzyko hipokaliemii, a także zmniejsza działanie diabetogenne. Lek ten jest szczegól nie polecany w terapii osób starszych i z dużym ryzykiem sercowo-naczyniowym.