This comprehensive guide demystifies the complex landscape of Amazon EC2, from fundamentals to advanced concepts. You’ll begin by understanding EC2 core components, creating and managing AMIs, selecting the right instance type and size, establishing networking and connectivity, and implementing security best practices. Next, you’ll start building resilient apps on EC2, load balancing, auto scaling, storage options, performance optimization, monitoring, logging, and auditing. You'll also explore advanced concepts like containers, serverless, hybrid/multi-cloud architectures, high performance computing, big data, and disaster recovery strategies. By the end, you'll be equipped with the knowledge and confidence to harness the full potential of Amazon EC2.